Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer
Identifieur interne : 000192 ( an2020/Analysis ); précédent : 000191; suivant : 000193Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer
Auteurs : Ying Wu [République populaire de Chine] ; Yuexiao Tang [République populaire de Chine] ; Shangzhi Xie [République populaire de Chine] ; Xiaoxiao Zheng [République populaire de Chine] ; Shufen Zhang [République populaire de Chine] ; Jiayan Mao [République populaire de Chine] ; Baoming Wang [République populaire de Chine] ; Yuerou Hou [République populaire de Chine] ; Liqiang Hu [République populaire de Chine] ; Kequn Chai [République populaire de Chine] ; Wei Chen [République populaire de Chine]Source :
- Theranostics [ 1838-7640 ] ; 2020.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis. Insights into the roles of MicroRNAs (miRNAs) in diseases, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches.
Url:
DOI: 10.7150/thno.38327
PubMed: 31938057
PubMed Central: 6956805
Affiliations:
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PMC:6956805Le document en format XML
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Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Tang, Yuexiao" sort="Tang, Yuexiao" uniqKey="Tang Y" first="Yuexiao" last="Tang">Yuexiao Tang</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetics, Institute of Genetics, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Genetics, Institute of Genetics, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Xie, Shangzhi" sort="Xie, Shangzhi" uniqKey="Xie S" first="Shangzhi" last="Xie">Shangzhi Xie</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zheng, Xiaoxiao" sort="Zheng, Xiaoxiao" uniqKey="Zheng X" first="Xiaoxiao" last="Zheng">Xiaoxiao Zheng</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Shufen" sort="Zhang, Shufen" uniqKey="Zhang S" first="Shufen" last="Zhang">Shufen Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Mao, Jiayan" sort="Mao, Jiayan" uniqKey="Mao J" first="Jiayan" last="Mao">Jiayan Mao</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Wang, Baoming" sort="Wang, Baoming" uniqKey="Wang B" first="Baoming" last="Wang">Baoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Hou, Yuerou" sort="Hou, Yuerou" uniqKey="Hou Y" first="Yuerou" last="Hou">Yuerou Hou</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Hu, Liqiang" sort="Hu, Liqiang" uniqKey="Hu L" first="Liqiang" last="Hu">Liqiang Hu</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chai, Kequn" sort="Chai, Kequn" uniqKey="Chai K" first="Kequn" last="Chai">Kequn Chai</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Hangzhou 310012</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">Theranostics</title><idno type="eISSN">1838-7640</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis. Insights into the roles of MicroRNAs (miRNAs) in diseases, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches.</p><p><bold>Methods:</bold> Here, we employed a novel chimeric peptide supramolecular nanoparticle delivery system for plectin-1 (PL-1)-targeted PDAC-specific miR-9 delivery <italic>in vitro</italic> and in pancreatic cancer patient-derived xenograft (PDX) model. RT-PCR and immunohistochemistry (IHC) were conducted to detect the expression pattern of eIF5A2. mRFP-GFP-LC3 fluorescence microscopy and Western blot were carried out to determine autophagy. Luciferase reporter assays were performed to elucidate the regulatory role of miR-9/eIF5A2 axis.</p><p><bold>Results:</bold> PL-1/miR-9 nanocomplexes dramatically improve the anticancer effect of doxorubicin through downregulating eIF5A2 expression to inhibit autophagy and induce apoptosis in PDAC therapy<italic> in vivo</italic>. Mechanistically, miR-9 directly targets the <italic>eIF5A2</italic> transcript by binding to its 3'-untranslated region (3'-UTR) to reduce the expression levels and the secreted protein of eIF5A2 in PDAC cells.</p><p><bold>Conclusion:</bold> PL-1/miR-9 nanoparticles can be used as a novel promising anti-cancer strategy with tumor targeting and miR-9/eIF5A2 may serve as a new potential therapeutic target for future synergic therapy against human PDAC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author><author><name sortKey="Mariotto, Ab" uniqKey="Mariotto A">AB Mariotto</name></author><author><name sortKey="Kramer, Jl" uniqKey="Kramer J">JL Kramer</name></author><author><name sortKey="Rowland, Jh" uniqKey="Rowland J">JH 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uniqKey="Bauer T">TW Bauer</name></author><author><name sortKey="Williams, M" uniqKey="Williams M">M Williams</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name></region><name sortKey="Chai, Kequn" sort="Chai, Kequn" uniqKey="Chai K" first="Kequn" last="Chai">Kequn Chai</name><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><name sortKey="Hou, Yuerou" sort="Hou, Yuerou" uniqKey="Hou Y" first="Yuerou" last="Hou">Yuerou Hou</name><name sortKey="Hu, Liqiang" sort="Hu, Liqiang" uniqKey="Hu L" first="Liqiang" last="Hu">Liqiang Hu</name><name sortKey="Mao, Jiayan" sort="Mao, Jiayan" uniqKey="Mao J" first="Jiayan" last="Mao">Jiayan Mao</name><name sortKey="Tang, Yuexiao" sort="Tang, Yuexiao" uniqKey="Tang Y" first="Yuexiao" last="Tang">Yuexiao Tang</name><name sortKey="Tang, Yuexiao" sort="Tang, Yuexiao" uniqKey="Tang Y" first="Yuexiao" last="Tang">Yuexiao Tang</name><name sortKey="Wang, Baoming" sort="Wang, Baoming" uniqKey="Wang B" first="Baoming" last="Wang">Baoming Wang</name><name sortKey="Xie, Shangzhi" sort="Xie, Shangzhi" uniqKey="Xie S" first="Shangzhi" last="Xie">Shangzhi Xie</name><name sortKey="Zhang, Shufen" sort="Zhang, Shufen" uniqKey="Zhang S" first="Shufen" last="Zhang">Shufen Zhang</name><name sortKey="Zheng, Xiaoxiao" sort="Zheng, Xiaoxiao" uniqKey="Zheng X" first="Xiaoxiao" last="Zheng">Xiaoxiao Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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